What is ankylosing spondylitis?

Ankylosing spondylitis (AS) is a chronic inflammatory disease that primarily affects the spine. It can also involve other parts of the body, such as the shoulders, hips, knees, neck, and pelvis. If left untreated, it can lead to spinal fusion, reducing mobility.

Signs and symptoms of AS include:

  • morning back pain and stiffness
  • spinal inflammation
  • pain in lower back and hips
  • fatigue
  • reduced physical function
  • less mobility
father with ankylosing spondylitis hugging son outside

What makes AS different from back pain?

Back pain is also known as mechanical pain. This pain is common and is typically caused by injury or overuse. It usually goes away after 6 weeks; any longer and it may be a sign of something more serious.

However, ankylosing spondylitis is a type of chronic, inflammatory back pain. AS occurs when the immune system mistakenly attacks healthy joints, mainly in the spine. The symptoms listed above may last for 3 months or longer. These symptoms may come and go, but because this is a chronic autoimmune disease, there is no cure. The good news is there are many ways to manage AS.

Learn more

Your treatment options

There are many treatment options out there, so it’s important to talk to your doctor to find the one that’s right for you.

Some treatment options include:

  • Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Over-the-counter medications like aspirin and ibuprofen, but can also include prescription products, which help to reduce inflammation, joint pain, and stiffness
  • Conventional Disease-Modifying Antirheumatic Drugs (DMARDs): Typically for more severe symptoms, these attempt to slow or stop joint/tissue damage and the progression of psoriatic arthritis
  • Biologics: A biologic is a protein-based medication produced from living cells that targets specific parts of the immune system
  • Surgery: In severe cases of AS, surgery to correct posture may be needed
  • Other alternatives: Certain exercises, physical therapy, good posture practices, and the use of heat and/or cold compresses may be helpful to relax muscles and reduce joint pain
mom with ankylosing spondylitis making a sandcastle with daughter
ankylosing spondylitis couple sitting down on the sidewalk embracing

How does Taltz work for patients with ankylosing spondylitis?

Taltz is a biologic. A biologic is a protein-based drug produced from living cells. Different from traditional systemic drugs that impact the entire immune system, biologics target specific parts of the immune system.

Purpose and Safety Summary

Important Facts About Taltz® (tȯl-ts). It is a prescription medicine also known as ixekizumab.
Taltz is an injectable medicine used to treat adults:

  • With moderate to severe plaque psoriasis. It is for people who may benefit from taking injections or pills (systemic therapy) or treatment using ultraviolet or UV light (phototherapy).
  • With active psoriatic arthritis.
  • With active ankylosing spondylitis.

  • Taltz affects the immune system. It may increase your risk of infections, which can be serious. Do not use Taltz if you have any symptoms of infection, unless your doctor tells you to. If you have a symptom after starting Taltz, call your doctor right away.
  • Your doctor should check you for tuberculosis (TB) before you start Taltz, and watch you closely for signs of TB during and after treatment with Taltz.
  • If you have TB, or had it in the past, your doctor may treat you for it before you start Taltz.
  • Do not use Taltz if you have had a serious allergic reaction to ixekizumab or any other ingredient in Taltz, such as: swelling of your eyelids, lips, mouth, tongue or throat, trouble breathing, feeling faint, throat or chest tightness, or skin rash. Get emergency help right away if you have any of these reactions. See the Medication Guide that comes with Taltz for a list of ingredients.
  • Crohn’s disease or ulcerative colitis (inflammatory bowel disease) can start or get worse with Taltz use. Tell your doctor if you have any of these symptoms or if they get worse: stomach pain, diarrhea, and weight loss.
  • You should not get live vaccines while taking Taltz. You should get the vaccines you need before you start Taltz.
Common side effects
The most common side effects of Taltz include:
  • Injection site reactions
  • Upper respiratory infections
  • Nausea
  • Fungal infections
Tell your doctor if you have any side effects.You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch.
Before using
Before you use Taltz, review these questions with your doctor:
❑ Are you being treated for an infection?
❑ Do you have an infection that does not go away or keeps coming back?
❑ Do you have TB or have you been in close contact with someone with TB?
❑ Do you have possible symptoms of an infection such as fever, cough, sores, diarrhea, or other symptoms? Ask your doctor about other possible symptoms.
❑ Do you have Crohn’s disease or ulcerative colitis?
Tell your doctor if:
❑ You need any vaccines or have had one recently.
❑ You are under age 18. Taltz has not been approved in people under 18 years of age.
❑ You take prescription or over-the-counter medicines, vitamins, or herbal supplements.
❑ You are pregnant or planning to become pregnant. It is not known if Taltz can harm an unborn baby.
❑ You are breastfeeding or planning to breastfeed. It is not known if Taltz passes into breastmilk.
How to take
See the instructions for use that come with Taltz. There you will find information about how to store, prepare, and inject Taltz.
Learn more
For more information, call 1-800-545-5979 or go to taltz.com.
This summary provides basic information about Taltz and is not comprehensive. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your doctor. Be sure to talk to your doctor or other healthcare provider about Taltz and how to take it. Your doctor is the best person to help you decide if Taltz is right for you.
Taltz® is a registered trademark owned or licensed by Eli Lilly & Company, its subsidiaries, or affiliates.

Please click to access the full Prescribing Information and Medication Guide. Please click to access Instructions for Use included with your device.