At first use, over 94% of adult patients with moderate to severe plaque psoriasis agreed that the Taltz autoinjector was “easy to use” and were confident in their ability to use it.

To learn how to use Taltz, watch the video or read the Instructions for Use that come with your autoinjector.

Even if you have given yourself and injection before, it is important to know that the Taltz autoinjector has different instructions from any device you may have used in the past.

If you are enrolled in Taltz Together, a Companion in Care can help connect you to a registered nurse who can provide injection support in-home or over the phone. Learn more

For other important administration and preparation instructions, talk to your doctor and refer to the Instructions for Use that come with your device.

Learn more

Taltz abbreviated steps to inject

Taltz autoinjector in locked position

Step 1

Make sure the device is in the lock position.
Twist off the base cap in the direction of the arrows.

Taltz autoinjector turn lock ring to unlock device

Step 2

Place the base of the device flat and firmly against injection site.
Turn the lock ring to the unlock position.

Taltz autoinjector press green injection button until the device clicks

Step 3

Press the green injection button.
You will hear a loud click, which means the injection has started.

Taltz autoinjector listen for second click

Step 4

Listen for a second click about 10 seconds later. The second click means the injection is complete.
Do not remove injector from skin until you’ve heard the second click.

Once you’ve completed the injection, dispose of your device in the Taltz sharps container or another puncture-resistant container with a secure lid. Do not dispose of in household trash.

IMPORTANT: These are not the complete instructions for using the autoinjector. Please see Instructions for Use that come with your device.

recommended areas to inject Taltz

When taking Taltz, please remember

  • Take your device out of the refrigerator and let it sit for 30 minutes to warm to room temperature. Leave the base cap/cap on the device while it is warming up to room temperature
  • You may inject the medicine into your stomach (abdomen) or thigh
  • Another person may give you the injection in the back of your arm
  • Alternate your injection site. Do not inject in the exact same spot every time
  • Do not inject within 1 inch of your belly button
  • Do not give an injection into areas where the skin is tender, bruised, red or hard, or in an area of skin that is affected by psoriasis

One of the most common side effects of Taltz is injection site reactions. However, most injection site reactions were mild to moderate and didn’t stop people from taking Taltz.

Before you or your caregiver inject for the first time, your healthcare provider should show you or your caregiver how to prepare and inject Taltz.

Important storage information

do not use Taltz if frozen

Do not use Taltz if it has been frozen.

protect Taltz from light

You should protect Taltz from light at all times.

do not shake Taltz

Do not shake your Taltz device.

Helpful injection tips

Talk to your doctor about whether the tips below may help with the injection of biologics.*

  • Placing something cold (such as an ice gel pack or cold water bottle) on the injection site before and after the injection may help reduce pain.
  • Acetaminophen may help relieve pain.
  • Antihistamines or topical corticosteroids may help with itching or swelling caused by the injection.
  • Choose different injection sites each time you inject.

The recommended places for injection are your stomach (abdomen) or thigh, and another person may give you the injection in the back of your arm.

Tips specific to Taltz

  • You should take Taltz out of the refrigerator and let it sit for 30 minutes to warm to room temperature before injecting. Leave the cap on the device while it is warming up to room temperature.
  • However, Taltz should not be microwaved, run under hot water, or left in direct sunlight.
  • There are 2 devices available for injecting Taltz: an autoinjector and a prefilled syringe.

*These tips have not been developed or studied specifically for Taltz.

Things to know

You may experience side effects while taking Taltz. If you do, please reach out to your doctor.

Injection site reactions

  • Injection site pain may occur while you are injecting. Other reactions, such as redness, may happen after several days
  • Most injection site reactions were mild to moderate and did not stop people from taking Taltz
  • Talk to your doctor about any injection site reactions

If you are experiencing injection site reactions with one type of device, talk to your doctor about whether it might be appropriate to switch to the other Taltz device.

The other most common side effects include:

  • Upper respiratory infections
  • Fungal skin infections
  • Nausea

These are not all of the possible side effects of Taltz. Serious side effects may occur. Tell your healthcare provider about any side effect that bothers you or that does not go away. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.

Lilly is currently monitoring and will continue to monitor and communicate additional information about injection site reactions. Please contact The Lilly Answers Center at 1-800-LillyRx (1-800-545-5979) if you have more questions about this topic.

Select Safety Information

The most common side effects of Taltz include: injection site reactions, upper respiratory infections, nausea and fungal skin infections. Tell your doctor if you have any side effects. You can report side effects at 1-800-FDA-1088 or

Purpose and Safety Summary

Important Facts About Taltz® (tȯl-ts). It is a prescription medicine also known as ixekizumab.

Taltz is an injectable medicine used to treat:

  • People six years of age and older with moderate to severe plaque psoriasis who may benefit from taking injections or pills (systemic therapy) or treatment using ultraviolet or UV light (phototherapy).
  • Adults with active psoriatic arthritis.
  • Adults with active ankylosing spondylitis.
  • Adults with active non-radiographic axial spondyloarthritis with objective signs of inflammation.
It is not known if Taltz is safe and effective in children for conditions other than plaque psoriasis or in children under 6 years of age.

  • Taltz affects the immune system. It may increase your risk of infections, which can be serious. Do not use Taltz if you have any symptoms of infection, unless your doctor tells you to. If you have a symptom after starting Taltz, call your doctor right away.
  • Your doctor should check you for tuberculosis (TB) before you start Taltz, and watch you closely for signs of TB during and after treatment with Taltz.
  • If you have TB, or had it in the past, your doctor may treat you for it before you start Taltz.
  • Do not use Taltz if you have had a serious allergic reaction to ixekizumab or any other ingredient in Taltz, such as: swelling of your eyelids, lips, mouth, tongue or throat, trouble breathing, feeling faint, throat or chest tightness, or skin rash. Get emergency help right away if you have any of these reactions. See the Medication Guide that comes with Taltz for a list of ingredients.
  • Crohn’s disease or ulcerative colitis (inflammatory bowel disease) can start or get worse with Taltz use. Tell your doctor if you have any of these symptoms or if they get worse: stomach pain, diarrhea, and weight loss.
  • You should not get live vaccines while taking Taltz. You should get the vaccines you need before you start Taltz.
Common side effects
The most common side effects of Taltz include:
  • Injection site reactions
  • Upper respiratory infections
  • Nausea
  • Fungal skin infections
Tell your doctor if you have any side effects. You can report side effects at 1-800-FDA-1088 or
Before using
Before you use Taltz, review these questions with your doctor:
❑ Are you being treated for an infection?
❑ Do you have an infection that does not go away or keeps coming back?
❑ Do you have TB or have you been in close contact with someone with TB?
❑ Do you have possible symptoms of an infection such as fever, cough, sores, diarrhea, or other symptoms? Ask your doctor about other possible symptoms.
❑ Do you have Crohn’s disease or ulcerative colitis?
Tell your doctor if:
❑ You need any vaccines or have had one recently.
❑ You take prescription or over-the-counter medicines, vitamins, or herbal supplements.
❑ You are pregnant or planning to become pregnant. It is not known if Taltz can harm an unborn baby.
❑ You are breastfeeding or planning to breastfeed. It is not known if Taltz passes into breastmilk.
How to take
See the instructions for use that come with Taltz. There you will find information about how to store, prepare, and inject Taltz. Adults may self-inject after receiving training from a healthcare provider.
For people under 18 years of age:
  • Weighing less than 50 kg (i.e., 110 lb): Taltz must be given by a healthcare provider.
  • Weighing more than 50 kg (i.e., 110 lb): If your healthcare provider decides that your caregiver may give your injections of Taltz at home, your caregiver should ask and receive training from a healthcare provider on the right way to prepare and inject Taltz.
Learn more
For more information, call 1-800-545-5979 or go to

This summary provides basic information about Taltz and is not comprehensive. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your doctor. Be sure to talk to your doctor or other healthcare provider about Taltz and how to take it. Your doctor is the best person to help you decide if Taltz is right for you.
Taltz® is a registered trademark owned or licensed by Eli Lilly and Company, its subsidiaries and affiliates.