How Taltz works for patients with psoriatic arthritis

Psoriatic arthritis can develop slowly with mild symptoms, or it can develop quickly and be severe. Early recognition, diagnosis, and treatment of psoriatic arthritis can help prevent or limit progressive joint damage that occurs in later stages of the disease.

IL-17A is one protein in your body that plays a role in inflammation and mediates bone and cartilage damage. Taltz works to help block IL-17A within your body.*

*The relationship between the mechanism of action and clinical outcomes has not been determined.

How Taltz Works

Is Taltz right for you?

Taltz is a biologic (injection) prescription medication used to treat adults with active psoriatic arthritis.

What is a biologic?

A biologic is a protein-based drug produced from living cells. Biologics are different from traditional systemic drugs that impact the entire immune system. Biologics instead target specific parts of the immune system.

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Embrace the chance of joint symptom improvement

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Joint symptom improvement

Taltz helped more than half of people experience joint symptom improvement at 24 weeks, including less joint pain and stiffness, plus improved mobility.

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Helps stop progression

For some people, Taltz is proven to help stop the progression of joint damage caused by psoriatic arthritis at week 16.

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Perform daily activities

Taltz improved the ability of some people at 24 weeks to perform daily activities such as getting in and out of bed, dressing themselves, going for walks, gripping objects, reaching for objects high and low, maintaining personal hygiene, and tying their shoes.

And if you also have plaque psoriasis, learn how Taltz can help you achieve clearer skin here.

Select Important Safety Information - Do not use Taltz if you have had a severe allergic reaction to ixekizumab or any of the other ingredients in Taltz. If you have a severe allergic reaction, do not take another injection of Taltz.

Find a rheumatologist

Finding the right rheumatologist is important. If you need help locating one, please click below for a list of rheumatologists provided by the National Psoriasis Foundation.

Indications and Important Safety Information

Taltz is a prescription medicine used to treat adults with active psoriatic arthritis. Taltz is also a treatment for adults with moderate to severe plaque psoriasis who may benefit from taking injections or pills (systemic therapy) or phototherapy (treatment using ultraviolet or UV light).

Important Safety Information

Do not use Taltz if you have had a severe allergic reaction to ixekizumab or any of the other ingredients in Taltz. See the Medication Guide for a complete list of ingredients in Taltz. If you have a severe allergic reaction, do not take another injection of Taltz.

Taltz is a medicine that affects your immune system and may lower the ability of your immune system to fight infections. Taltz may increase your risk of infections, which can sometimes become serious.

  • Your healthcare provider (HCP) should check you for tuberculosis (TB) before you begin treatment with Taltz and may treat you for TB if you have a history of TB or have TB
  • Your HCP should watch you closely for signs and symptoms of TB during and after treatment with Taltz
Before Starting Taltz

Before starting Taltz, tell your HCP(s) if you

  • are being treated for an infection
  • have an infection that does not go away or that keeps coming back
  • have or have had TB, or have been in close contact with someone with TB
  • think you have an infection or have symptoms of an infection, such as
    • fever, sweats, or chills
    • muscle aches
    • cough
    • shortness of breath
    • blood in your phlegm (mucus)
    • weight loss
    • warm, red, or painful skin or sores on your body
    • diarrhea or stomach pain
    • burning when you urinate or urinating more often than usual
  • have Crohn’s disease or ulcerative colitis
  • recently received or are scheduled to receive an immunization (vaccine). People who take Taltz should not receive live vaccines. Prior to starting Taltz, consider completion of all age-appropriate immunizations according to current immunization guidelines
  • are pregnant or plan to become pregnant. It is not known if Taltz can harm your unborn baby
  • are breastfeeding or plan to breastfeed. It is not known if Taltz passes into your breast milk
After Starting Taltz

After starting Taltz, call your HCP right away if you have any of the symptoms of infection listed above. Do not use Taltz if you have any symptoms of infection, unless you are instructed to by your HCP.

Talk to Your Doctor

Tell your HCP about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Serious Side Effects

Taltz may cause serious side effects, including

  • Serious allergic reactions. Get emergency medical help right away if you get any of the following symptoms of a serious allergic reaction:
    • feeling faint
    • swelling of your face, eyelids, lips, mouth, tongue, or throat
    • trouble breathing or throat tightness
    • chest tightness
    • skin rash
  • Inflammatory bowel disease (Crohn’s disease or ulcerative colitis) can happen during treatment with Taltz, including worsening symptoms. Tell your HCP if you have new or worsening symptoms of inflammatory bowel disease during treatment with Taltz, including stomach pain, diarrhea (with or without blood in stool), or weight loss
Common Side Effects

The most common side effects of Taltz include: injection site reactions, nausea, fungal infections, and upper respiratory infections. These are not all of the possible side effects of Taltz. Tell your HCP about any side effect that bothers you or that does not go away.

Additional Information

Call your HCP for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.

Store Taltz in the refrigerator, and protect it from light. Do not freeze Taltz or use Taltz if it has been frozen. Do not shake Taltz.

Taltz is available by prescription only.

Please click to access the full Prescribing Information and Medication Guide. Please click to access Instructions for Use included with your device.